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Effects of long-term PPI therapy
One of the most commonly used medicines in the general population is PPI (e.g. omeprazole, esomeprazole, pantoprazole, Rabeprazole, etc.) aka “gas medicine”. For any tummy upset, one of the medicines will be due to gas or acidity. Nowadays, the prazole group of drugs is preferred over antacids or H2-blocker! However, it has some demerits if used for a long time!
- It is associated with reduced absorption of iron, B12, and magnesium.
- It is also associated with a small but increased risk of osteoporosis and bone fractures.
- The drugs also predispose to gut infections with bacteria such as Salmonella, Campylobacter, and possibly Clostridium difficile.
- It increases the risk of helicobacter-associated (a bacterium in the stomach) waste away from the stomach's inner lining (medically it is called gastric mucosal atrophy).
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